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About the Laboratory

The Dendritic Cell Research group (DCR) is directed by Professor Derek Hart. They discover key immune markers and biological processes which will provide new diagnostic and therapeutic products for improving patient care.

The group studies DC surface molecules to determine how these molecules influence DC function and how antibodies targeting them might be used in clinical practice.  A major part of our work is aimed at using the patient’s immune responses to treat haematological cancers.

We are testing our findings in preclinical models of stem cell transplantation, leukaemia, multiple myeloma, prostate cancer and other malignancies.

We are striving to develop novel immunosuppressive strategies, including our previous anti-CD83 antibody as a novel therapeutic agent. We aim to use this antibody to improve transplant outcomes, whilst preserving the patient’s ability to fight infections and cancer. Negotiations to support a clinical trial of anti-CD83 in allogeneic haematopoietic stem cell transplantation are underway.

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About Our People

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Professor Derek Hart

Prof Hart has made major scientific and clinical contributions, particularly in relation to his special interest in dendritic cells (DC), immunotherapy and BMT. He is a Rhodes Scholar and RCPA Distinguished Fellow Prof Hart directed the Christchurch Clinical Haematology Unit and BMT Unit and left it with a significant research reputation, including UK MRC trial participation… more

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Associate Professor Georgina Clark

Associate Professor Georgina Clark completer her PhD in molecular immunology at the University of Melbourne. She continued her studies in leucocyte surface molecules undertaking postdoctoral work at the University of Oxford, UK and the University of Otago, New Zealand where she joined Professor Hart’s group studying the molecules found on the surface of dendritic cells… more

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Dr Pablo Silveira 

Dr Silveira was awarded his PhD from the University of Sydney for research analysing the genetic mechanisms conferring susceptibility to autoimmune gastritis… more

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Dr Xinsheng Ju

Dr Xinsheng Ju studied medicine for six years and received another three year medical science training in China, then he moved back to clinic as a haematologist… read more

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Dr Phillip Fromm

Dr Phillip Fromm completed a PhD in cellular immunology elucidating the role of tumor necrosis factor and its receptors in the development of dendritic cells… more

Our Research Specialities

Graft Versus Host Disease

Developing diagnostics and therapeutics for use in patients with graft versus host disease.

Dendritic cells (DC) are a special type of white blood cell that instruct the immune system. We have shown that  changes in a specific type of DC can predict for the major complication in bone marrow transplantation …read more

Vaccine for AML

Therapeutic Vaccine for Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) affects around 900 Australians yearly, most commonly elderly patients. With current treatments, the overall survival rate is less than 10% for patients above 60 and at best 40% in younger individual…read more

Prostate Cancer Vaccine

Therapeutic Vaccine for Prostate Cancer

Prostate cancer is the most common cancer in Australian men and new therapies are needed. We can train the immune system to fight cancer by vaccinating patients using specialised white blood cells, called dendritic cells…read more

Transplant Outcomes

Specific Immuno- suppression to improve transplant outcomes

Current treatments for transplant patients suppress their whole immune system, making them susceptible to infections and cancer. We developed a therapeutic antibody that targets a molecule on a small population of active immune cells…read more

Dendritic Cell Research

The ANZAC Research Institute
Concord Repatriation General Hospital
Gate 3, Hospital Road
Concord NSW 2139, Australia

P: +61 2 9767 9100
F: +61 2 9767 9101

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