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About the Laboratory
The Dendritic Cell Research group (DCR) is directed by Associate Professor Georgina Clark. They discover key immune markers and biological processes which will provide new diagnostic and therapeutic products for improving patient care.
The group studies DC surface molecules to determine how these molecules influence DC function and how antibodies targeting them might be used in clinical practice. A major part of our work is aimed at using the patient’s immune responses to treat haematological cancers.
We are testing our findings in preclinical models of stem cell transplantation, leukaemia, multiple myeloma, prostate cancer and other malignancies.
We are striving to develop novel immunosuppressive strategies, including our previous anti-CD83 antibody as a novel therapeutic agent. We aim to use this antibody to improve transplant outcomes, whilst preserving the patient’s ability to fight infections and cancer. Negotiations to support a clinical trial of anti-CD83 in allogeneic haematopoietic stem cell transplantation are underway.
Latest News and Events
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Sydney Catalyst – Cancer Immunology Education Dinner
Cancer Immunology Education Dinner Date Wednesday 31 July 2019 Time Networking canapes and drinks from 5.00pm, Dinner from 6.00pm...
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DC Down Under Symposium 2019 – Registration Form
Download, complete registration form and return to dcr.admin@sydney.edu.au by Friday 26 July 2019
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Dr Silveira presents at The Transplantation Society Conference
On my way to The Transplantation Society (TTS) conference in Spain, I stopped off in Oxford UK, where I...
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2015 – What a Year for DCR!
2015 has been a great year for Dendritic Cell Research. DC Down Under 2015 was another great success. With...
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Stuck on what to buy your colleague this Christmas for Kris Kringle?
When you have only $10 or $20 to spend, it can sometimes be difficult to find a gift which...
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Dendritic Cell Image for all to see
This is an image of a dendritic cell taken at 100x magnification. Dendritic cells are specialised cells in the...
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New clinical antibody created using the science of gene cloning
Dendritic Cell Research Publish Landmark Paper Dendritic Cell Research (DCR) has a major interest in Dendritic Cell (DC)...
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Dreadlocks anyone?
Cristian Silveira donates money raised to Dendritic Cell Research Cristian Silveira had been growing his hair for about 17...
About Our People
Professor Derek Hart
Prof Hart made major scientific and clinical contributions, particularly in relation to his special interest in dendritic cells (DC), immunotherapy and BMT. He was a Rhodes Scholar and RCPA Distinguished Fellow. Prof Hart directed the Christchurch Clinical Haematology Unit and BMT Unit and left it with a significant research reputation, including UK MRC trial participation. …..read more
Associate Professor Georgina Clark
A/Prof Clark set up Dendritic Cell Research (DCR) at the ANZAC Research Institute alongside the late Professor Derek Hart. Her interest lies in translational research developing antibodies to leucocyte surface molecules into immune therapies. The group’s translational pipeline from discovery of novel molecules (CD300 family, CD302, CD205, CD83, CMRF-56, CMRF-44) expressed by myeloid lineage cells including dendritic cells…..read more
Dr Pablo Silveira
Dr Silveira joined the Dendritic Cell Research Group in 2012, where his research is focussed on novel molecules on dendritic cells that can be used as therapeutic targets to control inflammation associated with haematopoietic stem cell transplantation, solid organ transplantation or autoimmune disease…read more
Dr Xinsheng Ju
r Ju re-joined Professor Derek Hart, Dendritic Cell Research group in 2014 to continue his long term interests on DC biology and targeting CD83 molecule to control graft versus host disease (GVHD) and treat haematological malignancies…. read more
Our Research Specialities
Dendritic Cell Research
The ANZAC Research Institute
Concord Repatriation General Hospital
Gate 3, Hospital Road
Concord NSW 2139, Australia
P: +61 2 9767 9100
F: +61 2 9767 9101
E: dcr.admin@sydney.edu.au
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